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Symptoms of overdose incorporate hypotension and tachycardia or bradycardia. Terlipressin could be given to take care of hypotension and tachycardia if typical vasopressors fall short to regulate hypertension.

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Irbesartan is a selected aggressive antagonist of AT1 receptors having a Considerably bigger affinity (greater than 8500-fold) to the AT1 receptor than with the AT2 receptor, and no agonist activity.

Blockade in the AT1 receptor gets rid of the adverse comments of angiotensin II on renin secretion, even so the resulting elevated plasma renin exercise and circulating angiotensin II tend not to conquer the consequences of irbesartan on hypertension.

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